HALLUCINOGENS MDMA-Ecstasy
MDMA
(3,4 methylenedioxymethamphetamine) is a synthetic, psychoactive drug chemically
similar to the stimulant methamphetamine and the hallucinogen mescaline. Street
names for MDMA include Ecstasy, Adam, XTC, hug, beans, and love drug. MDMA is
an illegal drug that acts as both a stimulant and psychedelic, producing an energizing
effect, as well as distortions in time and perception and enhanced enjoyment from
tactile experiences.
MDMA exerts its primary effects in the brain on neurons
that use the chemical serotonin to communicate with other neurons. The serotonin
system plays an important role in regulating mood, aggression, sexual activity,
sleep, and sensitivity to pain.
Research in animals indicates that MDMA
is neurotoxic; whether or not this is also true in humans is currently an area
of intense investigation. MDMA can also be dangerous to health and, on rare occasions,
lethal.
Heatlh Effects For some people, MDMA can be addictive.
A survey of young adult and adolescent MDMA users found that 43 percent of those
who reported ecstasy use met the accepted diagnostic criteria for dependence,
as evidenced by continued use despite knowledge of physical or psychological harm,
withdrawal effects, and tolerance (or diminished response), and 34 percent met
the criteria for drug abuse. Almost 60 percent of people who use MDMA report withdrawal
symptoms, including fatigue, loss of appetite, depressed feelings, and trouble
concentrating.
Cognitive Effects Chronic users of MDMA perform
more poorly than nonusers on certain types of cognitive or memory tasks. Some
of these effects may be due to the use of other drugs in combination with MDMA,
among other factors.
Physical Effects In high doses, MDMA can
interfere with the body’s ability to regulate temperature. On rare but unpredictable
occasions, this can lead to a sharp increase in body temperature (hyperthermia),
resulting in liver, kidney, and cardiovascular system failure, and death.
Because
MDMA can interfere with its own metabolism (breakdown within the body), potentially
harmful levels can be reached by repeated drug use within short intervals.
Users
of MDMA face many of the same risks as users of other stimulants such as cocaine
and amphetamines. These include increases in heart rate and blood pressure, a
special risk for people with circulatory problems or heart disease, and other
symptoms such as muscle tension, involuntary teeth clenching, nausea, blurred
vision, faintness, and chills or sweating.
Psychological Effects These
can include confusion, depression, sleep problems, drug craving, and severe anxiety.
These problems can occur during and sometimes days or weeks after taking MDMA.
Neurotoxicity Research in animals links MDMA exposure to long-term
damage to neurons that are involved in mood, thinking, and judgment. A study in
nonhuman primates showed that exposure to MDMA for only 4 days caused damage to
serotonin nerve terminals that was evident 6 to 7 years later. While similar neurotoxicity
has not been definitively shown in humans, the wealth of animal research indicating
MDMA's damaging properties suggests that MDMA is not a safe drug for human consumption.
Hidden
Risk: Drug Purity Other drugs chemically similar to MDMA, such as MDA
(methylenedioxyamphetamine, the parent drug of MDMA) and PMA (paramethoxyamphetamine,
associated with fatalities in the U.S. and Australia) are sometimes sold as ecstasy.
These drugs can be neurotoxic or create additional health risks to the user. Also,
ecstasy tablets may contain other substances in addition to MDMA, such as ephedrine
(a stimulant); dextromethorphan (DXM, a cough suppressant that has PCP-like effects
at high doses); ketamine (an anesthetic used mostly by veterinarians that also
has PCP-like effects); caffeine; cocaine; and methamphetamine. While the combination
of MDMA with one or more of these drugs may be inherently dangerous, users might
also combine them with substances such as marijuana and alcohol, putting themselves
at further physical risk. For more information on our South
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Information
contained in this page is courtesy of The National Institute on Drug Abuse (NIDA)
for more information on MDMA-Ecstasy please visit: http://www.nida.nih.gov/Infofacts/ecstasy.html
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