STIMULANTS
ABUSE AND ADDICTION
What are stimulants? As
the name suggests, stimulants increase alertness, attention, and energy, as well
as elevate blood pressure and increase heart rate and respiration. Stimulants
historically were used to treat asthma and other respiratory problems, obesity,
neurological disorders, and a variety of other ailments. But as their potential
for abuse and addiction became apparent, the medical use of stimulants began to
wane. Now, stimulants are prescribed for the treatment of only a few health conditions,
including narcolepsy, ADHD, and depression that has not responded to other treatments.
How do stimulants affect the brain
and body? Stimulants, such as dextroamphetamine (Dexedrine and Adderall)
and methylphenidate (Ritalin and Concerta), have chemical structures similar to
a family of key brain neurotransmitters called monoamines, which include norepinephrine
and dopamine. Stimulants enhance the effects of these chemicals in the brain.
Stimulants also increase blood pressure and heart rate, constrict blood vessels,
increase blood glucose, and open up the pathways of the respiratory system. The
increase in dopamine is associated with a sense of euphoria that can accompany
the use of these drugs.
What are
the possible consequences of stimulant use and abuse? As with other drugs
of abuse, it is possible for individuals to become dependent upon or addicted
to many stimulants. Withdrawal symptoms associated with discontinuing stimulant
use include fatigue, depression, and disturbance of sleep patterns. Repeated use
of some stimulants over a short period can lead to feelings of hostility or paranoia.
Further, taking high doses of a stimulant may result in dangerously high body
temperature and an irregular heartbeat. There is also the potential for cardiovascular
failure or lethal seizures.
Is it
safe to use stimulants with other medications? Stimulants should be used
in combination with other medications only under a physician's supervision. Patients
also should be aware of the dangers associated with mixing stimulants and OTC
cold medicines that contain decongestants; combining these substances may cause
blood pressure to become dangerously high or lead to irregular heart rhythms.
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Information contained in this
page is courtesy of The National Institute on Drug Abuse (NIDA) for more information
on STIMULANTS please visit: http://www.drugabuse.gov/ResearchReports/Prescription/prescription4.html#Stimulants
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